Motor Neurone Disease
Causes of neuron degeneration in motor neurone disease
The major form of motor neurone disease is amyotrophic lateral sclerosis (ALS). This degenerative condition involves selective degeneration of motor neurons in the neocortex, brain stem and spinal cord. Using a combination of in vivo and in vitro techniques, as well as relevant transgenic mouse models and advanced cellular imaging, we are investigating the pathological processes underlying motor neuron degeneration. We have a particular focus on axonal abnormalities that precede frank neuronal degeneration.
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