Professor David Small
(03) 6226 7348
0402 682 843
23, Hobart TAS 7000
Professorial Research Fellow
(03) 6226 2679
Professor Small's research interests centre on the molecular neurobiology of Alzheimer's disease. In collaboration with Dr Lisa Foa and Dr. Kaylene Young (Menzies) and Profs Mibel Aguilar and Helena Parkington (Monash University), his team is looking at basic mechanisms of disease causation with a view to the development of novel therapeutic strategies.
Petratos S, Li QX, George AJ, Hou X, Kerr ML, Unabia SE, Hatzinisirioui I, Maksel D, *Small DH. The β-amyloid protein (A&beta) of Alzheimer's disease increases CRMP-2 levels and phosphorylation through a Rho-GTPase-dependent mechanism thereby inhibiting tubulin assembly in neurons. Brain 2008; 131, 90-108.
Sáez-Valero J, Sberna G, McLean CA, Masters CL, *Small DH. Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer;s disease. Lancet 1997; 350, 929.
*Small DH, Mok SS, Bornstein JC. Alzheimer's disease and A&beta Toxicity: from top to bottom. Nature Reviews Neuroscience 2001; 2, 595-598.
*Small DH. Do cholinesterase inhibitors boost synaptic scaling in Alzheimer's disease? Trends in Neuroscience 2004; 27, 245-249.
* Denotes Menzies Researcher
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