Neonatal Respiratory Group
The Neonatal Respiratory Group aims to understand the pathogenesis and pathophysiology of neonatal respiratory disease, develop and evaluate therapies for infants with respiratory failure, and improve the ventilatory and supportive care provided to such infants.
The research activities of the group have 4 sub-themes:
Sub-theme 1. Innovation in surfactant therapy
Exogenous surfactant therapy has been a cornerstone of treatment for preterm infants for two decades. The broad objective of this research theme is to extend the therapeutic possibilities for surfactant in neonates with lung disease.
Sub-theme 2. Optimisation of lung volume during mechanical ventilation
In providing ventilatory support to babies with respiratory failure, clinicians face the difficult task of applying ventilation in such a way as to avoid atelectasis and overdistension without having a bedside measure of absolute lung volume. The broad objective of this research theme is to find methods to optimise lung volume during both conventional mechanical ventilation (CMV) and high frequency oscillatory ventilation (HFOV), using new technologies that can be applied at the bedside.
Sub-theme 3. Neonatal oximetry and oxygen therapy
This theme has the broad objective of delivering oxygen more effectively and efficiently to hypoxic infants.
Sub-theme 4. Evidence-based medicine in neonatology
This theme has the broad objective of assembling evidence regarding neonatal respiratory management, with a focus on therapies of current interest to the Menzies Neonatal Respiratory Group.
- Investigation of minimally-invasive surfactant therapy in preterm infants on continuous positive airway pressure (CPAP)
- Mechanisms of epithelial injury and surfactant dysfunction in meconium aspiration syndrome (MAS)
- Evaluation of dilute surfactant lavage in ventilated infants with MAS
- Measurement of regional distribution of tidal ventilation as an aid in setting positive end-expiratory pressure during CMV
- Relationship of real-time changes in oxygen saturation with changes in fraction of inspired oxygen in infants receiving oxygen.
- Application of a closed-loop oxygen control system with an apnoea/hypoventilation detector and an advanced control algorithm in management of infants receiving oxygen.
- Cochrane review: Surfactant via brief tracheal catheterisation for prevention of morbidity and mortality in preterm infants with or at risk of respiratory distress syndrome.
- Cochrane review: Lung lavage for meconium aspiration syndrome in newborn infants.
- Cochrane review: Bolus surfactant therapy for meconium aspiration
- Cochrane review: Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation.
- Cochrane review: Prophylactic methylxanthine for prevention of apnoea in preterm infants.
- Cochrane review: Methylxanthine treatment for apnoea in preterm infants.
- Cochrane review: High frequency oscillatory ventilation versus conventional ventilation for infants with severe pulmonary dysfunction born at or near term.
Related Funding Bodies
- Royal Hobart Hospital Research Foundation
- Chiesi Farmaceutici
- National Health and Medical Research Council of Australia
- Professor Peter Dargaville (Honorary Research Fellow)
- Dr Tony De Paoli
- Dr Angela Gerber
- Dr Katharine Squires
- Associate Professor Tim Gale
- Mr Deip Khong (Honours Student)
- Professor Peter Davis, Royal Women's Hospital, Melbourne
- Professor John Carlin, Murdoch Children's Research Institute
- Dr David Tingay, Royal Children's Hospital, Melbourne
- Dr Raffaele Dellacá, Politecnico di Milano, Milan, Italy
- Dr Peter Rimensberger, University of Geneva, Switzerland
- Professor Inéz Frerichs