The Genetics of Leber's Hereditary Optic Neuropathy
Leber's Hereditary Optic Neuropathy (LHON) is a rare form of visual impairment which occurs in young adults, particularly men. It is caused by the degeneration of retinal ganglion cells, which leads to loss of central vision. LHON is maternally inherited and is primarily caused by mutations in the mitochondria, the energy powerhouses of cells. However there are other genetic factors involved in LHON and we are searching for these factors by studying families with LHON from Thailand.
- Dr Russell Thomson (Research Fellow)
- Bussaraporn Kunhapan, Mahidol University, Thailand
- Associate Professor Patcharee Lertrit, Mahidol University, Thailand
- Dr Taisei Mushiroda, RIKEN, Japan