Towards a better understanding of uraemic molecules
Chronic kidney disease (CKD) is associated with premature death due to cardiovascular disease. People with kidney function less than 30 per cent are 10-times more likely to die of cardiovascular disease than reach dialysis. This finding occurs at all ages; young people with CKD develop cardiovascular disease at up to 100-times the rate of age-matched people with normal kidney function. At the present time, no specific markers identify people at excessive risk of cardiovascular death. Dialysis in its present form does not reduce this rate of death.
This study aims to identify molecules that signal early kidney disease, toxic molecules that contribute to symptomatic kidney disease & premature cardiovascular death and subsequently determine optimal treatment for the removal of these toxic molecules from people with end-stage kidney failure through the use of dialysis techniques and transplantation.
- Professor Matthew Jose (Honorary Member)