How do brain cells become brain cancer?

Protocadherins are a large family of proteins that are highly expressed by brain cells, including glial cells, and dysregulation of protocadherins is associated with the development of glioblastoma.  However, it is unclear how protocadherins influence glial cell function and contribute to tumour development.  We are using a combination of cell culture and shRNA gene knockdown approaches alongside cre-lox transgenic mice, CRISPR/Cas9 gene editing and confocal microscopy to investigate the role of protocadherins in glial and cancer biology.