Microvascular Blood Flow in Cardiovascular Disease
Insulin resistance and vascular dysfunction are strong predictors of cardiovascular disease. The older techniques of vascular function (skin LDF and large artery FMD) have been of limited value for understanding the mechanisms of the pathology or as predictive disease progression indicators. This project will provide a comprehensive assessment of vascular function related to insulin action and insulin resistance using original innovative techniques that provide new insights into the regulation of microvascular blood flow in muscle and skin. Combined with the older techniques essential information about the basic mechanisms that control microvascular perfusion in normal healthy subjects will be gained, which will provide a greater understanding of the effects of the vascular pathologies involved in insulin resistance and cardiovascular disease.
Postgraduate enquiries are welcome, please contact:
- Dr John Newman
- Dr Sandi Powell