Novel Assessment of the Role of Vasomotion in Controlling Muscle Metabolism
This project will investigate the importance of vasomotion in insulin action on microvascular flow in muscle using novel approaches to laser Doppler flowmetry (LDF). We will also be looking at defects in vasomotion in pathophysiological states that may contribute to insulin resistance and diabetes.
A better understanding of insulin action and insulin resistance should provide a basis for development of methodologies for the early detection of microvascular dysfunction in human subjects. In particular, the use of the high power LDF probe, which predominantly reflects muscle blood flow will allow for the non-invasive assessment of muscle microvascular blood flow. Early detection of microvascular dysfunction will have significant economic and social benefits to Australia as this would allow for improved treatment outcomes.
Given there are currently one million diabetics in Australia, as the population ages, the cost of this disease is only going to increase. Any improvement in the diagnosis and treatment of diabetes (particularly if it is inexpensive and easy) would make a significant contribution to the health of our ageing population.
- Eloise Bradley (Research Assistant)
- Professor Erik Richter - August Krogh Institute, Denmark