Cognition and type 2 Diabetes in Older Tasmanians (CDOT) Studies

The CDOT studies are aimed at understanding the contribution of type 2 diabetes mellitus to brain health. Type 2 diabetes may lead to brain disease by affecting the health of blood vessels, but may also directly affect brain cells (neurons). Understanding how this happens may provide us with ways to reduce the burden of cognitive impairment and dementia in the population.

CDOT is a large cohort study of people with type 2 diabetes in whom sensitive measurements of blood vessel and brain health are undertaken over a few years. The primary cohort study has been active since 2008 with funding from the National Health and Medical Research Council. The NHMRC has provided further funding to extend this study with specialized measurements of blood pressure, to see if alterations in blood pressure may influence brain health in people with diabetes. In another study funded by Alzheimers Australia, the benefit of physical activity to brain health is being studied in people with type 2 diabetes.

These studies are both ongoing participant-based studies.

Research Projects

Cognition and type 2 Diabetes in Older Tasmanians: a study of vascular mechanisms (CDOT-BP) - Participant Information Sheet (PDF 366.4KB).

Cognition and type 2 Diabetes in Older Tasmanians: a randomised control trial of Exercise (CDOT-X) - Participant Information Sheet (PDF 295.3KB).

Research Groups

Related Diseases


Senior Members

Team Members

  • Adam Kane (Psychologist)
  • Kate Butorac (Project Manager)
  • Kate Probert (Project Assistant)
  • Marylyn Uren (Volunteer)
  • Jane Cato (Volunteer)
  • Wendy Davidson (Volunteer)
  • Dianne Bogus (Volunteer)
  • Veronica Griggs (Volunteer)

Doctoral Students

  • Penny Veloudi
  • Chris Moran
  • Chris Karaiyannis
  • Fateme Zabetiantarghi
  • Dawn Simpson

Internal Collaborators

External Collaborators

  • Professor David Bruce - University of Western Australia
  • Professor Robyn Daly - Deakin University
  • Professor Tim Greenaway
  • Professor Alun Hughes - Imperial College, London
  • Associate Professor Richard Beare - Monash University
  • Associate Professor Coralie English - The University of Newcastle
  • Associate Professor Thanh Phan - Monash University
  • Associate Professor Gerald Muench - University of Western Sydney
  • Dr Toby Cumming - Florey Institute, Melbourne
  • Dr Justin Davies - Imperial College, London
  • Dr Amanda Wood - University of Birmingham

Related Publications

You can Veiw all of Michele Callisaya's publications here:

You can veiw all of Professor Velandai Srikanth's publications here: