Dr Stephen Richards
(03) 6226 2673
23, Hobart TAS 7000
Senior Research Fellow
(03) 6226 2703
Dr Richards joined the Muscle Diabetes Research Group in 2000 after post-doctoral positions at the University of Melbourne, Baker Institute, and Alfred Hospital in Melbourne, and INSERM U390 in Montpellier, France, working on cardiac metabolism and preservation in normal and failing hearts. In addition to doing research with Menzies, Dr Richards teaches undergraduate biochemistry for the University of Tasmania School of Medicine, and coordinates Honours and post-graduate students doing research projects for Menzies.
The Muscle Diabetes Research Group has developed techniques for measuring microvascular blood flow within muscle in humans and animals. Importantly, the group (including Professor Stephen Rattigan and Dr Michelle Keske) has shown muscle blood flow to be an important determinant of the sensitivity of muscle to insulin, and that reduced blood flow responses to insulin contribute to insulin resistance, and possibly the development of type 2 diabetes. Dr Richards' research aims to determine why the microvascular actions of insulin are impaired in insulin resistant animal models, and aims to find ways of enhancing muscle blood flow responses to insulin. Two current methods for achieving this focus on (i) the role of the adipocyte-derived hormone adiponectin, and (ii) augmenting the biochemical signalling used by insulin to increase muscle microvascular blood flow, namely the nitric oxide-cyclic GMP pathway, with a view to the development of novel therapeutics.
*St Pierre P, *Genders AJ, *Keske MA, *Richards SM, *Rattigan S. Loss of insulin-mediated microvascular perfusion in skeletal muscle is associated with the development of insulin resistance. Diabetes Obesity Metab. In press May 2010
McLean S, *Richards SM, Cover S-L, Brandon S, Davies NW, Bryant JP, Clausen TP. Papyriferic acid, An Antifeedant Triterpene from Birch Trees, Inhibits Succinate Dehydrogenase from Liver Mitochondria J Chem Ecol. 2009; 35: 1252-1261
*Newman JM, *Dwyer RM, St-Pierre P, *Richards SM, *Clark MG, *Rattigan S. Decreased microvascular vasomotion and myogenic response in rat skeletal muscle in association with acute insulin resistance. J Physiol. 2009; 587(Pt 11): 2579-2588.
*Ponsonby AL, *Blizzard CL, *Pezic A, *Cochrane J, Ellis J, Morley R, *Dickinson JL, *Patterson B, Sale ML, *Richards SM, *Dwyer T. Adiposity gain during childhood, ACE I/D polymorphisms and metabolic outcomes. Obesity 2008; 16: 2141-2147.
Ross R, Downey KA, *Newman JMB, *Richards SM, *Clark MG, *Rattigan S. Contrast enhanced ultrasound measurement of microvascular perfusion relevant to nutrient and hormone delivery in skeletal muscle: a model study in vitro. Microvasc Res. 2008; 75: 323-329 [IF 3.00]
*Newman JM, *Ross RM, *Richards SM, *Clark MG, *Rattigan S. Insulin and contraction increase nutritive blood flow in rat muscle in vivo determined by microdialysis of L-[14C]glucose. J Physiol. 2007; 585(Pt 1):217-29.
*Rattigan S, *Bussey CT, *Ross RM, *Richards SM. Obesity, insulin resistance and capillary recruitment (invited review). Microcirculation 2007; 14: 299-309.
Mahajan H, Kolka CM, *Newman JMB, *Rattigan S, *Richards SM, *Clark MG. Vascular and metabolic effects of methacholine in relation to insulin action in muscle Diabetologia 2006; 49: 713-723.
Mahajan H, *Richards SM, *Rattigan S, *Clark MG. Local methacholine but not bradykinin potentiates insulin-mediated capillary recruitment and glucose uptake in muscle in vivo. Diabetologia 2004; 47: 2226-34.
* Denotes Menzies Researcher